How does leptin work in relation to fat loss?
Now, let’s examine the two different ways in which the body reacts when it gets the leptin signal and when it doesn’t. Let’s say you had a soft drink. The sugar in it starts filling up your fat cells. Once they’re filled, the brain gets the message and the SNS is then increased. What happens then is that you get an energy spike also known as having a “sugar-high”. Your brain looks at this as an opportunity to expend energy by using your fat deposits as an extra available energy.
Resistance to leptin
We concluded thus far that releasing leptin stimulates the sympathetic nervous system. If the brain can’t get the leptin message, it assumes it’s hungry, forcing it to slow down on most of the metabolic processes in order to preserve energy. Even in the previous example of drinking a soft drink or a soda, if that person is leptin resistant, their body doesn’t realize it’s just ingested food. This leaves the person hungry and trying to eat more food in the effort to get the brain off of thinking that they are starving. Nutritional scientists have concluded that overweight people release bigger amounts of leptin in comparison to lean people.
What they found was that overweight people regularly experience high levels of leptin and have an ineffective response mechanism to it. This is usually known as being “leptin resistant”, that is related to the ineffective transport of leptin through the brain-blood barrier. This results in decreased leptin signaling to the hypothalamus and increased food consumption and fat gain in the liver and adipose tissues.
What this means is that that the leptin molecules aren’t binding with the receptors in the brain that tells your brain to require more food (the reason why plasma levels are increased). That’s why it is essential that you incorporate regular re-feeds in your diet. This will provide many positive psychological benefits, as well as boost your metabolism.